An inpatient study of the effects of buprenorphine on cigarette smoking in men concurrently dependent on cocaine and opioids

• Published in: Nicotine & tobacco research 2002-05, Vol.4 (2), p.223-228
• Main Authors: Mutschler, Nicole H., Stephen, Bruce J., Teoh, Siew Koon, Mendelson, Jack H., Mello, Nancy K.
• Format: Article
• Language: English
• Subjects: Administration, Sublingual; Adult; Biological and medical sciences; BRIEF REPORT; Buprenorphine - administration & dosage; Buprenorphine - pharmacology; Cocaine-Related Disorders - drug therapy; Drug addictions; Humans; Inpatients; Male; Medical sciences; Narcotic Antagonists - administration & dosage; Narcotic Antagonists - pharmacology; Opioid-Related Disorders - drug therapy; Smoking; Toxicology; Treatment Outcome
• ISSN: 1462-2203; 1469-994X
• DOI: 10.1080/14622200210124012

The effect of sublingual buprenorphine on cigarette smoking was examined in 23 adult men with DSM III-R diagnosis of concurrent opiate and cocaine dependence. After admission to a clinical research ward, subjects were detoxified with methadone (10–50 mg/day), then were drug-free for 6 days before random assignment to either 4 or 8 mg/day of buprenorphine. Gradually increasing daily sublingual doses of buprenorphine were administered for 5 days, then subjects were maintained on 4 or 8 mg/day of buprenorphine for 12 days. Each subject's preferred brand of cigarettes was available ad libitum throughout the study. Five responses (FR 5) on a key were required to earn each cigarette. The time and number of cigarettes were recorded by an automated cigarette dispenser. Subjects acquired significantly more cigarettes during the buprenorphine induction and maintenance phases (25.5±2.0) than during the drug-free phase (18.5±1.8; p