Chlorhexidine vaginal wipes prior to elective cesarean section: does it reduce infectious morbidity? A randomized trial

Objective: To evaluate the efficacy of preoperative vaginal cleansing using chlorhexidine 0.25% antiseptic wipes on rates of postcesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection). Methods: This prospective randomized trial was conducted among 218 preg...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2017-06, Vol.30 (12), p.1484-1487
Main Authors: Ahmed, Magdy R., Aref, Nisreen K., Sayed Ahmed, Waleed A., Arain, Farzana R.
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Adult
Anti-Infective Agents, Local - administration & dosage
Antibiotic Prophylaxis - methods
Case-Control Studies
Cesarean section
Cesarean Section - adverse effects
chlorhexidine
Chlorhexidine - administration & dosage
Endometritis - prevention & control
Female
Humans
infectious morbidity
Pregnancy
Prospective Studies
Surgical Wound Infection - prevention & control
Young Adult
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Summary:Objective: To evaluate the efficacy of preoperative vaginal cleansing using chlorhexidine 0.25% antiseptic wipes on rates of postcesarean section (CS) infectious morbidities (endometritis, febrile morbidity and wound infection). Methods: This prospective randomized trial was conducted among 218 pregnant women scheduled for term elective CS. Patients were equally divided into two groups by simple randomization. After spinal anesthesia and catheterization under aseptic technique, the study group had preoperative vaginal cleansing using chlorhexidine 0.25% antiseptic wipes for about 1 min, while the control group did not. All cases received the prophylactic antibiotics and the usual abdominal scrub. All participants received the routine postoperative care without other interventions. Adverse postcesarean infectious morbidities such as endometritis, febrile morbidity and wound infection were observed at the time of hospital discharge and weekly for 6 weeks postpartum. Results: Both groups were matched regarding the baseline patients' characteristics (age, gestational age, BMI, operative time and postoperative hospital stay). Overall, post-CS infectious morbidity were significantly reduced from 24.4% in the control group to 8.8% in the intervention group; p value 
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2016.1219996