Impacts on prenatal development of the human cerebellum: a systematic review

Purpose: The cerebellum is essential for normal neurodevelopment and is particularly susceptible for intra-uterine disruptions. Although some causal prenatal exposures have been identified, the origin of neurodevelopmental disorders remains mostly unclear. Therefore, a systematic literature search w...

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Published in:The journal of maternal-fetal & neonatal medicine 2017-10, Vol.30 (20), p.2461-2468
Main Authors: Koning, Irene V., Tielemans, Myrte J., Hoebeek, Freek E., Ecury-Goossen, Ginette M., Reiss, Irwin K. M., Steegers-Theunissen, Regine P. M., Dudink, Jeroen
Format: Article
Language:English
Subjects:
cerebellum
Cerebellum - embryology
Female
growth and development
human
Humans
Maternal Exposure - adverse effects
Pregnancy
prenatal
Prenatal Injuries
Systematic review
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Summary:Purpose: The cerebellum is essential for normal neurodevelopment and is particularly susceptible for intra-uterine disruptions. Although some causal prenatal exposures have been identified, the origin of neurodevelopmental disorders remains mostly unclear. Therefore, a systematic literature search was conducted to provide an overview of parental environmental exposures and intrinsic factors influencing prenatal cerebellar growth and development in humans. Materials and methods: The literature search was limited to human studies in the English language and was conducted in Embase, Medline, Cochrane, Web of Science, Pubmed and GoogleScholar. Eligible studies were selected by three independent reviewers and study quality was scored by two independent reviewers. Results: The search yielded 3872 articles. We found 15 eligible studies reporting associations between cerebellar development and maternal smoking (4), use of alcohol (3), in vitro fertilization mediums (1), mercury (1), mifepristone (2), aminopropionitriles (1), ethnicity (2) and cortisol levels (1). No studies reported on paternal factors. Conclusions: Current literature on associations between parental environmental exposures, intrinsic factors and human cerebellar development is scarce. Yet, this systematic review provided an essential overview of human studies demonstrating the vulnerability of the cerebellum to the intra-uterine environment.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2016.1253060