Serum collectrin levels in patients with early- and late-onset preeclampsia

Aim: The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). To assess the correlation between serum collectrin levels and blood pressure in humans. Material and methods: This cross-sectional study was conducted...

Full description

Saved in:
Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2018-11, Vol.31 (21), p.2827-2831
Main Authors: Aslan Cetin, Berna, Aydogan Mathyk, Begum, Cift, Tayfur, Tuten, Abdullah, Bulut, Berk, Yilmaz, Nevin, Erenel, Hakan, Ekmekci, Hakan, Gezer, Altay
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Collectrin
Cross-Sectional Studies
Female
Humans
hypertension
Membrane Glycoproteins - blood
Pre-Eclampsia - blood
preeclampsia
Pregnancy
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim: The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). To assess the correlation between serum collectrin levels and blood pressure in humans. Material and methods: This cross-sectional study was conducted including 79 pregnant women, 27 with normal pregnancy, 30 with EOPE and 22 with LOPE. Maternal serum levels of collectrin were measured by using enzyme-linked immunosorbent assay kits. Results: The mean serum collectrin level was significantly lower in women with PE compared with the control group (8.49 ± 3.12 ng/ml (EOPE), 9.69 ± 3.01 ng/ml (LOPE) versus 11.51 ± 4.33 ng/ml) and was found to be the lowest in the EOPE group (8.49 ± 3.12 ng/ml). The mean serum urea and uric acid levels were significantly higher in the PE group than the control group. Serum collectrin concentrations did not correlate with maternal age, BMI and serum creatinine levels. However, collectrin concentrations were negatively correlated with systolic blood pressure (r = −0.284, p = .011) and diastolic blood pressure (r = −0.275, p = .014) as well as with maternal serum urea (r = −0.269, p = .017) and uric acid (r = −0.219, p = .049) concentrations. Conclusion: Maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group. There is an inverse correlation between serum collectrin levels and blood pressure.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2017.1357692