An Asian multicenter retrospective study on persistent pulmonary hypertension of the newborn: incidence, etiology, diagnosis, treatment and outcome

Objectives: To explore the incidence, etiologies, diagnostic methods, treatment options and outcomes in neonates with persistent pulmonary hypertension of the newborn (PPHN) and to identify mortality risk factors in a study from six Asian countries. Methods: A retrospective chart review of patients...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2020-06, Vol.33 (12), p.2032-2037
Main Authors: Nakwan, Narongsak, Jain, Suksham, Kumar, Kishore, Hosono, Shigeharu, Hammoud, Majeda, Elsayed, Yasser Yahia, Ariff, Shabina, Hasan, Babar, Khowaja, Waqar, Poon, Woei Bing
Format: Article
Language:English
Subjects:
Asia - epidemiology
Asian country
Birth Weight
Case-Control Studies
developing country
Echocardiography
High-Frequency Ventilation - adverse effects
Humans
Incidence
Infant, Newborn
Infant, Premature
Meconium Aspiration Syndrome - epidemiology
multicenter retrospective study
newborn
Persistent Fetal Circulation Syndrome - diagnosis
Persistent Fetal Circulation Syndrome - etiology
Persistent Fetal Circulation Syndrome - mortality
Persistent Fetal Circulation Syndrome - therapy
persistent pulmonary hypertension of the newborn
Retrospective Studies
Sildenafil Citrate - therapeutic use
Vasodilator Agents - therapeutic use
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Summary:Objectives: To explore the incidence, etiologies, diagnostic methods, treatment options and outcomes in neonates with persistent pulmonary hypertension of the newborn (PPHN) and to identify mortality risk factors in a study from six Asian countries. Methods: A retrospective chart review of patients with documented PPHN from seven centers in six Asian countries (Japan, Kuwait, India, Pakistan, Singapore, and Thailand) between 1 January, 2014 and 31 December, 2016, was performed. Results: A total of 369 PPHN infants were identified. The incidence of PPHN ranged from 1.2 to 4.6 per 1000 live births. The all-cause mortality rate was 20.6% (76 of 369). Meconium aspiration syndrome was the primary cause of PPHN (24.1%). In most cases (84.8%) echocardiography was used to establish the diagnosis of PPHN. Sildenafil was the most commonly used pulmonary vasodilator (51.2%). Multivariate multiple regression analysis indicated gestational age
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2018.1536740