Effect of withholding feeds on transfusion-related acute gut injury in preterm infants: a pilot randomized controlled trial

Background: Several retrospective studies have reported an increase in necrotizing enterocolitis (NEC) during the 48 h following red blood cell (RBC) transfusion. Whether withholding enteral feeding during transfusion decreases the risk of transfusion-associated acute gut injury (TRAGI) in preterm i...

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Published in:The journal of maternal-fetal & neonatal medicine 2020-12, Vol.33 (24), p.4139-4144
Main Authors: Sahin, Suzan, Gozde Kanmaz Kutman, H., Bozkurt, Ozlem, Yavanoglu Atay, Funda, Emre Canpolat, F., Uras, Nurdan, Suna Oguz, S., Underwood, Mark A.
Format: Article
Language:English
Subjects:
Enterocolitis, Necrotizing - epidemiology
Enterocolitis, Necrotizing - etiology
Feeding
Gastrointestinal Microbiome
Humans
Infant
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature
necrotizing enterocolitis
Perfusion Index
Pilot Projects
prematurity
Retrospective Studies
TRAGI
transfusion
transfusion-associated necrotizing enterocolitis (TANEC)
withholding feeds
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Summary:Background: Several retrospective studies have reported an increase in necrotizing enterocolitis (NEC) during the 48 h following red blood cell (RBC) transfusion. Whether withholding enteral feeding during transfusion decreases the risk of transfusion-associated acute gut injury (TRAGI) in preterm infants is unclear. Study design and methods: In this pilot study, 112 preterm infants with gestational age ≤32 weeks and/or birth weight ≤1500 g were randomly assigned to withholding (NPO) or continuance of feeding (FED) during RBC transfusion. Primary outcome measure was development of NEC (stage ≥ 2) within 72 h of a transfusion and the change in abdominal circumference. Results: One hundred fifty-four transfusion episodes (74 NPO and 80 FED) were analyzed. Demographic characteristics were found to be similar in both groups. There was no difference in rates of NEC (0 versus 3.4%; p = .49) between the NPO and FED groups. The incidence of feeding intolerance was higher in the FED group; however, it was statistically insignificant (1.9 versus 6.8%, p = .36). Abdominal circumference remained similar in both groups in all three consecutive days following transfusion (p>.05). Conclusion: This pilot study does not support withholding feedings during transfusion but is not adequately powered to test the hypothesis that NPO decreases NEC rates. Adequately powered well-designed multicenter trials are still required.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2019.1597844