The influence of zinc supplementation on metabolic status in gestational diabetes: a meta-analysis of randomized controlled studies

• Published in: The journal of maternal-fetal & neonatal medicine 2021-07, Vol.34 (13), p.2140-2145
• Main Authors: Li, Xiujuan, Zhao, Jinqiu
• Format: Article
• Language: English
• Subjects: Diabetes, Gestational - drug therapy; Diabetes, Gestational - prevention & control; Dietary Supplements; Female; Gestational diabetes; Humans; Insulin; meta-analysis; metabolic status; Pregnancy; randomized controlled trials; Randomized Controlled Trials as Topic; Research Design; Zinc; zinc supplementation
• ISSN: 1476-7058; 1476-4954
• DOI: 10.1080/14767058.2019.1659769

Zinc supplementation has emerged as an important approach to improve metabolic status in gestational diabetes. However, its use has not been well established. We conduct a systematic review and meta-analysis to evaluate the efficacy of zinc supplementation to improve metabolic status for gestational diabetes. PubMed, Embase, and the Cochrane Central Register of Controlled Trials are searched. Randomized controlled trials (RCTs) assessing the influence of zinc supplementation (or its combination) versus placebo on metabolic status of gestational diabetes are included. Two investigators independently have searched articles, extracted data, and assessed the quality of included studies. Meta-analysis is performed using the random-effect model. Five RCTs involving 263 patients are included in the meta-analysis. Compared with control intervention for gestational diabetes, zinc supplementation is associated with significantly reduced FPG (std. MD = −0.52; 95% CI = −0.82 to −0.21; p = .0008), insulin (std. MD = −0.68; 95% CI = −0.98 to −0.37; p