Nutrition, epigenetic markers and growth in preterm infants

Maternal diet and early nutrition of newborns may affect the phenotype later in adulthood. Susceptibility of epigenetic mechanisms to the nutritional environment is a critical element in neonatal development. Epigenetic mechanisms could be considered as a bridge between environmental stimuli and lon...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2021-12, Vol.34 (23), p.3963-3968
Main Authors: Tozzi, Maria Giulia, Moscuzza, Francesca, Michelucci, Angela, Scaramuzzo, Rosa T., Cosini, Cinzia, Chesi, Francesca, Caligo, Maria Adelaide, Ciantelli, Massimiliano, Ghirri, Paolo
Format: Article
Language:English
Subjects:
Adult
Epigenesis, Genetic
Epigenetic markers
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
nutrition
Nutritional Status
postnatal growth
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Summary:Maternal diet and early nutrition of newborns may affect the phenotype later in adulthood. Susceptibility of epigenetic mechanisms to the nutritional environment is a critical element in neonatal development. Epigenetic mechanisms could be considered as a bridge between environmental stimuli and long lasting phenotype. IC2, a key region on 11p15, is involved in the control of growth and regulates CDKN1C, PHLDA2 and KCNQ1, growth inhibitor genes. Our aim was to investigate the relationship between epigenetic markers, nutrition and postnatal growth. We enrolled 37 newborns (gestational age at birth was
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2019.1702952