Midregional pro-adrenomedullin and matrix metalloproteinase-2 levels in intrauterine growth restriction and small gestational age pregnancies: biochemical diagnostic difference

• Published in: The journal of maternal-fetal & neonatal medicine 2021-06, Vol.34 (12), p.1999-2005
• Main Authors: Şahin, Banuhan, Soyer-Çalışkan, Canan, Çelik, Samettin, Hatırnaz, Şafak, Tinelli, Andrea
• Format: Article
• Language: English
• Subjects: Adrenomedullin; Cross-Sectional Studies; Female; Fetal Growth Retardation - diagnosis; Gestational Age; Humans; Intrauterine growth restriction; Matrix Metalloproteinase 2; midregional pro-adrenomedullin; Placenta; Pregnancy; pregnancy complications; small for gestational age
• ISSN: 1476-7058; 1476-4954
• DOI: 10.1080/14767058.2020.1846707

Midregional pro-adrenomedullin (MR-proADM) and matrix metalloproteinase-2 (MMP-2) are such proteins, that decreased levels are demonstrated in defective placental functions, as preeclampsia. The aim of the study is to compare maternal serum MR-proADM and MMP-2 levels across pregnancies with intrauterine growth restriction (IUGR), small for gestational age (SGA) and appropriate for gestational age (AGA), to biochemical screen the difference between SGA and IUGR. 180 pregnant women were enrolled in a cross-sectional study: sixty pregnancies diagnosed for IUGR were included in group 1 (IUGR group), sixty pregnancies with SGA were in Group 2 (SGA group) and sixty pregnancies diagnosed for AGA, as control group. Maternal venous blood samples were collected at the time of enrollment, to assess serum MR-proADM and MMP-2 levels, by enzyme-linked immunosorbent assay (ELISA). The mean maternal serum MR-proADM and MMP-2 levels were lower in the IUGR group than in the SGA and AGA groups (p