Antifungal metabolites from Blumea balsamifera

The leaves of Blumea balsamifera afforded icthyothereol acetate, cryptomeridiol, lutein, and β-carotene. The structures of icthyothereol acetate (1) and cryptomeridiol (2) were elucidated by extensive 1D and 2D NMR spectroscopy, while those of lutein and β-carotene were identified by comparison with...

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Bibliographic Details
Published in:Natural product research 2005-04, Vol.19 (3), p.231-237
Main Authors: Ragasa, Consolacion Y., Kristin C. Co, Angel Lyn, Rideout, John A.
Format: Article
Language:English
Subjects:
Alkynes - isolation & purification
Alkynes - pharmacology
Aspergillus niger
Asteraceae - chemistry
Bacillus subtilis
Blumea
Blumea balsamifera
Candida albicans
Compositae
Cryptomeridiol
Escherichia coli
Icthyothereol acetate
Lutein
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Naphthalenes - isolation & purification
Naphthalenes - pharmacology
Plant Extracts - pharmacology
Pyrans - isolation & purification
Pyrans - pharmacology
Staphylococcus aureus
Trichophyton mentagrophytes
β-Carotene
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Summary:The leaves of Blumea balsamifera afforded icthyothereol acetate, cryptomeridiol, lutein, and β-carotene. The structures of icthyothereol acetate (1) and cryptomeridiol (2) were elucidated by extensive 1D and 2D NMR spectroscopy, while those of lutein and β-carotene were identified by comparison with literature data. Antimicrobial tests indicated that 1 has moderate activity against the fungi Aspergillus niger, Trichophyton mentagrophytes, and Candida albicans, while 2 has low activity against A. niger, T. mentagrophytes, and C. albicans. Both compounds have no antimicrobial activity against Psuedomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410410001709773