Antioxidant activity of aryltetralone lignans and derivatives from Virola sebifera (Aubl.)

Aryltetralone lignans bearing methylenedioxy groups (1a-b; 2a-b) were isolated from seeds of Virola sebifera. Their antioxidant activities were evaluated by inhibition of lipid peroxidation as indicated by TBARS and chemiluminescence emission (CL) assays. The lignan 1c, 'having a 2′-hydroxy-4′,...

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Bibliographic Details
Published in:Natural product research 2005-10, Vol.19 (7), p.661-666
Main Authors: Rezende, Kênnia R., Davino, Solange C., Barros, Sílvia B.M., Kato, Massuo J.
Format: Article
Language:English
Subjects:
Antioxidant activity
Antioxidants - pharmacology
Aryltetralone lignans
Chemiluminescence emission
Lignans - chemistry
Lignans - pharmacology
Myristicaceae
Myristicaceae - chemistry
Seeds - chemistry
TBARS
Virola sebifera
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Summary:Aryltetralone lignans bearing methylenedioxy groups (1a-b; 2a-b) were isolated from seeds of Virola sebifera. Their antioxidant activities were evaluated by inhibition of lipid peroxidation as indicated by TBARS and chemiluminescence emission (CL) assays. The lignan 1c, 'having a 2′-hydroxy-4′,5′-methylenedioxyphenyl group, was the most active compound with TBARS/CL Q 1/2 values of 0.89 and 0.10 µg/mL, respectively. The catechol derivatives 3 and 4, obtained by demethylenation of lignans 1a and 2a, were of similar activity to 1c, and all were much more effective as antioxidants than α-tocopherol.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410412331302118