A new triterpene with antinociceptive activity from Maytenus robusta

• Published in: Natural product research 2006-12, Vol.20 (14), p.1315-1320
• Main Authors: Niero, Rivaldo, Mafra, Ana P., Lenzi, Ana C., Cechinel-Filho, Valdir, Tischer, Cesar A., Malheiros, Angela, De Souza, Marcia M., Yunes, Rosendo A., Delle Monache, Franco
• Format: Article
• Language: English
• Subjects: 3,15-Dioxo-21α-hydroxy friedelane; Analgesic activity; Analgesics - chemistry; Analgesics - isolation & purification; Analgesics - pharmacology; Animals; Brazil; Friedelanes; Male; Maytenus; Maytenus - chemistry; Maytenus robusta; Mice; Nuclear Magnetic Resonance, Biomolecular; Optical Rotation; Pain - drug therapy; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786410601101951

A new triterpene 3,15-dioxo-21α-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21α-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID 50 value of 12.5 ± 2.1 µmol kg −1 and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs.