A new anti-inflammatory flavonol glycoside from Alchornea floribunda leaves

Alchornea floribunda leaves are widely used in African ethnomedicine for the management of acute and chronic inflammatory disorders. In the present study, bioactivity-guided fractionation of the ethyl acetate fraction of the methanol leaf extract of the plant material led to the isolation of a new f...

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Bibliographic Details
Published in:Natural product research 2010-02, Vol.24 (3), p.266-273
Main Authors: Okoye, F.B.C., Osadebe, P.O.
Format: Article
Language:English
Subjects:
Alchornea
Alchornea floribunda
Animals
anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Edema - drug therapy
Euphorbiaceae
Euphorbiaceae - chemistry
flavonol glycoside
Flavonols - chemistry
Flavonols - pharmacology
Glycosides - chemistry
Glycosides - pharmacology
membrane stabilisation
Molecular Structure
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Rats
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Summary:Alchornea floribunda leaves are widely used in African ethnomedicine for the management of acute and chronic inflammatory disorders. In the present study, bioactivity-guided fractionation of the ethyl acetate fraction of the methanol leaf extract of the plant material led to the isolation of a new flavonol glycoside (AFF1). The anti-inflammatory activity of this novel compound was evaluated using egg albumen-induced rat paw oedema as a model of inflammation. AFF1 showed significant inhibition of the rat paw oedema in a dose-dependent manner. The activity of AFF1 (50 mg kg −1 ) was higher than that of the standard anti-inflammatory drug, aspirin (100 mg kg −1 ). The compound also significantly (p < 0.001) inhibited heat-induced haemolysis of human erythrocytes in vitro. The structure of AFF1 was elucidated as 3,5,7,3′-tetrahydroxyflavone-3-O-α-L-rhamnoside, using a combination of UV, IR, 1D and 2D (COSY) 1 H-NMR spectroscopy. This compound, in part, accounts for the anti-inflammatory effect of A. floribunda leaves.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786410902986894