Antioedematogenic activity, acetylcholinesterase inhibition and antimicrobial properties of Jacaranda oxyphylla

Jacaranda oxyphylla Cham. (Bignoniaceae) is a shrub found in the Brazilian cerrado and used in folk medicine to treat microbial infections. The aim of this study was to carry out a phytochemical screening and evaluate antioedematogenic, antimicrobial and antiacetylcholinesterase properties of J. oxy...

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Bibliographic Details
Published in:Natural product research 2016-09, Vol.30 (17), p.1974-1979
Main Authors: Pereira, V. V., Silva, R. R., dos Santos, M. H., Dias, D. F., Moreira, M. E. C., Takahashi, J. A.
Format: Article
Language:English
Subjects:
AChE inhibition
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
anti-inflammatory
antibacterial activity
Bacillus cereus - drug effects
Bignoniaceae
Bignoniaceae - chemistry
Brazil
Cholinesterase Inhibitors - isolation & purification
Cholinesterase Inhibitors - pharmacology
Edema - drug therapy
Escherichia coli - drug effects
Inflammation - drug therapy
Jacaranda oxyphylla
Medicine, Traditional
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Staphylococcus aureus - drug effects
Terpenes - isolation & purification
Terpenes - pharmacology
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Summary:Jacaranda oxyphylla Cham. (Bignoniaceae) is a shrub found in the Brazilian cerrado and used in folk medicine to treat microbial infections. The aim of this study was to carry out a phytochemical screening and evaluate antioedematogenic, antimicrobial and antiacetylcholinesterase properties of J. oxyphylla crude extracts. All extracts analysed showed presence of terpenoids, which are potentially active chemical substances. A high AChE inhibitory activity for hexane extract from leaves and for the extracts from twigs was found. Ethanol extract from leaves of J. oxyphylla showed activity against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli) bacteria. This extract was also effective in inhibiting the stages of inflammation evaluated. Biological investigation and phytochemical screening of J. oxyphylla extracts provided additional evidence of its traditional medicinal value.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2015.1095744