Spectroscopic characterisation of two polyketide metabolites from Cylindrocarpon sp. from driftwood

Two new polyketides, (5R,7R,9R)-7,9-dihydroxy-5-decanolide and (4E,6R,9R)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of Cylindrocarpon sp. SY-39 discovered during screening of driftwood at a Shonai coast area in Yamagata, Japan. The structures of 1 and 2 were determined usi...

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Bibliographic Details
Published in:Natural product research 2018-01, Vol.32 (1), p.60-64
Main Authors: Yoshida, Seiya, Suzuki, Takuma, Furuno, Hiroshi, Aboshi, Takako, Murayama, Tetsuya, Koseki, Takuya, Shiono, Yoshihito
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Antimicrobial activity
Aspergillus - drug effects
Cylindrocarpon sp
Driftwood
Hypocreales - chemistry
Japan
Magnetic Resonance Spectroscopy
Metabolites
Molecular Structure
Polyketides
Polyketides - chemistry
Spectroscopy
Staphylococcus aureus - drug effects
Stereoisomerism
Wood - microbiology
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Summary:Two new polyketides, (5R,7R,9R)-7,9-dihydroxy-5-decanolide and (4E,6R,9R)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of Cylindrocarpon sp. SY-39 discovered during screening of driftwood at a Shonai coast area in Yamagata, Japan. The structures of 1 and 2 were determined using a variety of spectroscopic methods. Compound 2 exhibited moderate antimicrobial activity against Staphylococcus aureus NBRC 13276 and Aspergillus clavatus F 318a at a concentration of 50 μg per disk.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1332616