Salicylaldehyde and dihydroisobenzofuran derivatives from the marine fungus Zopfiella marina

Two salicylaldehyde derivatives (1 and 2), a hydroxymethylphenol (3), five dihydroisobenzofuran (4-8) derivatives, and a 5-chloro-3-deoxyisoochracinic acid (9), together with a known 3-deoxyisoochracinic acid (10) were isolated from the marine fungus Zopfiella marina BCC 18240 (or NBRC 30420). The s...

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Bibliographic Details
Published in:Natural product research 2018-01, Vol.32 (2), p.149-153
Main Authors: Chokpaiboon, Supichar, Unagul, Panida, Nithithanasilp, Sutichai, Komwijit, Somjit, Somyong, Wiwat, Ratiarpakul, Thanawut, Isaka, Masahiko, Bunyapaiboonsri, Taridaporn
Format: Article
Language:English
Subjects:
Acids
Aldehydes - isolation & purification
Aldehydes - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Bacillus cereus - drug effects
Benzofurans - isolation & purification
Derivatives
dihydroisobenzofuran
Fungi
Fungi - chemistry
Marine Biology
Microbial Sensitivity Tests
Minimum inhibitory concentration
Molecular Structure
Mycobacterium tuberculosis - drug effects
obligate marine fungi
Salicylaldehyde derivative
Spectrum Analysis
Tuberculosis
Zopfiella marina
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Summary:Two salicylaldehyde derivatives (1 and 2), a hydroxymethylphenol (3), five dihydroisobenzofuran (4-8) derivatives, and a 5-chloro-3-deoxyisoochracinic acid (9), together with a known 3-deoxyisoochracinic acid (10) were isolated from the marine fungus Zopfiella marina BCC 18240 (or NBRC 30420). The structures of these compounds were elucidated by extensive spectroscopic analysis. Compound 1 showed weak antituberculous activity against Mycobacterium tuberculosis H37Ra, and antibacterial activity against Bacillus cereus with MIC values of 25 and 12.5 μg/mL, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1342083