Effect of polyphenols from Vicia faba L on lipase activity and melanogenesis

Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3′′-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2018-08, Vol.32 (16), p.1920-1925
Main Authors: Allam, Ahmed E., Nafady, Alaa M., Nakagawa, Toshinori, Takemoto, Naomichi, Shimizu, Kuniyoshi
Format: Article
Language:English
Subjects:
flavonoid glycosides
Flavonoids - chemistry
Flowers
Glycosides
Glycosides - chemistry
Humans
Inhibition
Kaempferol
Kaempferols
L-Rhamnopyranoside
Lipase
Lipase - drug effects
Lipase - metabolism
lipase and melanogenesis inhibition activities
Melanin
Melanins - antagonists & inhibitors
Melanins - biosynthesis
Melanoma
Molecular Structure
Polyphenols
Polyphenols - isolation & purification
Polyphenols - pharmacology
Skin
Vicia faba
Vicia faba - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new flavonoid glycosides, kaempferol 3-O-α-L-rhamnopyranosyl (1→6) (3′′-acetyl)-β-D-galactopyranoside 1 and kaempferol 3-O-α-L-arabinopyranosyl-5-O-α-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L. (Fabaceae). Methanol extract and the isolated compounds were tested against lipase and melanogenesis inhibition activities and resulted in that compound 2 showed 53 and 77% lipase inhibition activity in concentrations of 400 and 800 μg/mL, respectively. For melanogenesis, compounds 2, 3 and 4 exhibited potent melanogenesis inhibition activity where the melanin content in melanoma cells was decreased to be about 57.5, 56 and 61%, respectively, with no obvious melanocytotoxicity. The rest of compounds showed weak to moderate activity. The results of melanogenesis inhibition activity of this study suggested the potential use of Vicia faba flowers as a skin-whitening agent and reveal the flowers to be a rich source of important phytochemicals with antilipase and melanogenesis inhibitory activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1359169