A new indole-type alkaloid from the roots of Clematis florida var. plena

One new indole-type alkaloid, α-L-rhamnopyranosyl-(1→6)-β-D- glucopyranosyl 6-methoxy-3-indolecarbonate (1), together with three known alkaloids (2-4), one aromatic acid (5) and five known saponins (6-10), was isolated from the roots of Clematis florida var. plena. Their structures were established...

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Bibliographic Details
Published in:Natural product research 2019-10, Vol.33 (20), p.2925-2931
Main Authors: Sun, Kai-Hui, Ma, Xin-Hua, Zeng, Xian-Ming, Lin, Zhong-Yue, Cai, Yu-Mei, Zhang, Hai-Tao, Lin, Xiao-Yan, Feng, Shi-Biao, Zhong, Tian-Hua, Zhang, Yong-Hong
Format: Article
Language:English
Subjects:
Acids
alkaloid
Alkaloids
anti-inflammatory
Anti-inflammatory agents
Butanol
Clematis florida
Clematis florida var. plena
Dosage
Edema
Indoles
Inflammation
Inhibition
NMR
Nuclear magnetic resonance
Roots
Saponins
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Summary:One new indole-type alkaloid, α-L-rhamnopyranosyl-(1→6)-β-D- glucopyranosyl 6-methoxy-3-indolecarbonate (1), together with three known alkaloids (2-4), one aromatic acid (5) and five known saponins (6-10), was isolated from the roots of Clematis florida var. plena. Their structures were established by NMR spectroscopic analysis and acid hydrolysis. In in vivo anti-inflammatory activity, n-butanol extract was found to be potent against ear edema in mice, with inhibition rate of 48.7% at a dose of 800 mg/kg. Furthermore, compounds 8 and 9 obtained from the n-butanol extract exhibited significant anti-inflammatory activities with inhibition rates of 50.9% and 54.7% at a dose of 200 mg/kg.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1510396