Characterization, antibacterial activity and antibiotic modifying action of the Caryocar coriaceum Wittm. pulp and almond fixed oil

In this study the physicochemical characterization of the pulp and almond fixed oil was carried out; their antibacterial activity and aminoglycoside antibiotic modifying action against standard and multiresistant Gram-positive and -negative bacteria were investigated using the broth microdilution as...

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Bibliographic Details
Published in:Natural product research 2020-11, Vol.34 (22), p.3239-3243
Main Authors: Pereira, Fladson F.G., Feitosa, Maria K. S. B., Costa, Maria do S., Tintino, Saulo R., Rodrigues, Fábio F.G., Menezes, Irwin R. A., Coutinho, Henrique D. M., da Costa, José G.M., de Sousa, Erlânio O.
Format: Article
Language:English
Subjects:
Acidity
Aminoglycoside antibiotics
Aminoglycosides
Aminoglycosides - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antibacterial
Antibacterial activity
Antibiotics
Chemical composition
E coli
Escherichia coli - drug effects
fatty acid
Fatty acids
Fatty Acids - analysis
Gas Chromatography-Mass Spectrometry
Gram-negative bacteria
Malpighiales - chemistry
Microbial Sensitivity Tests
Minimum inhibitory concentration
Oils & fats
Pequi
Peroxide
Physical properties
Plant Oils - chemistry
Plant Oils - pharmacology
Pulp
Refractivity
Staphylococcus aureus - drug effects
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Summary:In this study the physicochemical characterization of the pulp and almond fixed oil was carried out; their antibacterial activity and aminoglycoside antibiotic modifying action against standard and multiresistant Gram-positive and -negative bacteria were investigated using the broth microdilution assay. Physical properties such as moisture, pH, acidity, peroxide index, relative density and refractive index indicate stability and chemical quality of the oils. In the GC/MS chemical composition analysis, a high unsaturated fatty acid content and the presence of oleic and palmitic acids were observed in the oils. In the antibacterial assay, more significant results were obtained for Escherichia coli, while other standard and multi-resistant strains presented MIC values ≥ 1024 μg/mL. Furthermore, the fixed oils in association with antibiotics were able to significantly improve antibacterial activity against S. aureus with a reduction in MICs.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1552955