Terpenoids and phenolics of Micromeria persica

Phytochemical investigation of the aerial parts of Micromeria persica led to the isolation of a new oleane type triterpenoid ester (1), together with six known compounds 2-7), comprising one phenyl ethanoid ester, one glycosylated flavonoid, two triterpenoids, and two steroids. Their structures were...

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Bibliographic Details
Published in:Natural product research 2020-10, Vol.34 (20), p.2913-2918
Main Authors: Kalaki Kordkolaei, Sakineh, Kanani, Mohammad Reza, Tabefam, Marzieh, Namazi Sarvestani, Nazanin, Hamburger, Matthias, Moridi Farimani, Mahdi
Format: Article
Language:English
Subjects:
Adenocarcinoma
Biotechnology
Breast
cytotoxic activity
Cytotoxicity
Flavonoids
Lamiaceae
MDA-MB231 cell line and DU145 cell line
Micromeria persica
NMR
Nuclear magnetic resonance
Phenols
Prostate cancer
Steroid hormones
Steroids
Terpenes
triterpenoid
Triterpenoids
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Summary:Phytochemical investigation of the aerial parts of Micromeria persica led to the isolation of a new oleane type triterpenoid ester (1), together with six known compounds 2-7), comprising one phenyl ethanoid ester, one glycosylated flavonoid, two triterpenoids, and two steroids. Their structures were elucidated by interpretation of their one-dimensional and two-dimensional NMR spectra and completed by the analysis of the HRESIMS data. Compounds 1 and 3 were evaluated for their cytotoxic feature against human breast adenocarcinoma cell line (MDA-MB231) and human prostate cancer cell line (DU145). However, they did not show positive effect (IC 50 > 75µM).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1598988