Effect of the proportion of curcuminoids on the gastroprotective action of Curcuma longa L. in rats

The gastroprotective effect of a turmeric acetone extract (TAE) (Curcuma longa L. [Zingiberaceae]) was evaluated and compared against its major curcuminoids; curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Additionally, to demonstrate the importance of the metabolites'...

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Bibliographic Details
Published in:Natural product research 2021-06, Vol.35 (11), p.1903-1908
Main Authors: Orona-Ortiz, Alejandra, Velázquez-Moyado, Josué A., Pineda-Peña, Elizabeth A., Balderas-López, José Luis, Tavares Carvalho, José Carlos, Navarrete, Andrés
Format: Article
Language:English
Subjects:
Acetone
Animal models
Animals
combination index-isobologram equation
curcuma
Curcuma - chemistry
Curcuma longa
Curcumin
Curcumin - chemistry
Curcumin - pharmacology
Diarylheptanoids - pharmacology
Ethanol
gastric ulcer
Metabolites
metabolites synergism
Natural products-interaction
Plant Extracts - chemistry
Plant Extracts - pharmacology
Protective Agents - pharmacology
Rats
Rats, Wistar
Stomach - drug effects
Stomach - pathology
Synergistic effect
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Summary:The gastroprotective effect of a turmeric acetone extract (TAE) (Curcuma longa L. [Zingiberaceae]) was evaluated and compared against its major curcuminoids; curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Additionally, to demonstrate the importance of the metabolites' ratio in the extract on the synergistic effect, different mixtures were evaluated. An ethanol-induced gastric injury model was used to evaluate the gastroprotection activity in Wistar rats. The pharmacologic interaction analysis was performed using the Combination Index (CI)-Isobologram Equation method. The CI calculated at 0.5 of affected fraction (fa) for the TAE indicated a synergistic interaction between its components. However, when the proportion of curcuminoids changed from 3.7:1:10 in TAE to a 1:1:1 ratio, the CI implied an antagonistic effect. The binary combinations of curcuminoids (1:1) also showed an antagonistic interaction. The results of this work suggest that the proportion of curcuminoids in the TAE is crucial for the gastroprotective effect against ethanol-induced damage.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1644504