A new diketopiperazine from an endophytic fungus Aspergillus aculeatus F027

A new diketopiperazine cyclo-(L-Phe-N-ethyl-L-Glu) (1), along with two known diketopiperazines cyclo-(L-Pro-L-Leu) (2) and cyclo-(L-Pro-L-Phe) (3) were isolated from the cultures of an endophytic fungus Aspergillus aculeatus F027. The structures of these compounds were elucidated based on spectrosco...

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Bibliographic Details
Published in:Natural product research 2021-07, Vol.35 (14), p.2370-2375
Main Authors: Ma, Haoran, Wang, Fuqian, Jin, Xiaoqi, Jiang, Jie, Hu, Song, Cheng, Lu, Zhang, Geng
Format: Article
Language:English
Subjects:
Antibacterial activity
Aspergillus aculeatus
diketopiperazine
E coli
Endophytes
endophytic fungus
Fungi
Pseudomonas aeruginosa
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Summary:A new diketopiperazine cyclo-(L-Phe-N-ethyl-L-Glu) (1), along with two known diketopiperazines cyclo-(L-Pro-L-Leu) (2) and cyclo-(L-Pro-L-Phe) (3) were isolated from the cultures of an endophytic fungus Aspergillus aculeatus F027. The structures of these compounds were elucidated based on spectroscopic data. The configurations of these compounds were determined by advanced Marfey's analysis. Antibacterial activity of the diketopiperazines against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were also evaluated. Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2019.1677652 .
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1677652