Two new nor-sesquiterpenoids from Fusarium tricinctum, an endophytic fungus isolated from Ligusticum chuanxiong

As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (1-2) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of Fusarium tricinctum, an endophytic fungus isolated from the root of...

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Bibliographic Details
Published in:Natural product research 2021-11, Vol.35 (21), p.3535-3539
Main Authors: Cao, Yu-Mei, Guo, Da-Le, Jin, Meng-Ying, Tan, Lu, Yang, Tian-Long, Deng, Fang, Gu, Yu-Cheng, Li, Xiao-Hua, Cao, Zhi-Xing, Deng, Yun
Format: Article
Language:English
Subjects:
cytotoxity
ECD calculations
endophytes
Fusarium tricinctum
Ligusticum chuanxiong
nor-sesquiterpenoids
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Summary:As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (1-2) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of Fusarium tricinctum, an endophytic fungus isolated from the root of Ligusticum chuanxiong. The structures of these two previously undescribed compounds were elucidated by interpretation of the spectroscopic evidences including NMR correlations as well as MS data. The absolute configurations of these two compounds were confirmed by TD-DFT-ECD calculations. An MTT assay indicated that compound 1 exhibited moderate cytotoxic activity against MV4-11 with an IC 50 value of 22.29 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1712385