Senegalin, a new phenylpropanoid and other secondary metabolites from the stem bark of Ekebergia senegalensis A. Juss. (Meliaceae)

Senegalin (1), a new phenylpropanoid has been isolated from the stem bark of Ekebergia senegalensis A. Juss. along with twelve known secondary metabolites including coumarins 2-5, 4-hydroxy-3,5-methylbenzoic acid (6), pentacyclic triterpenoids 7-9, acyclic triterpenoids 10 and 11 and steroids 12 and...

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Bibliographic Details
Published in:Natural product research 2021-11, Vol.35 (21), p.3694-3700
Main Authors: Kemayou, Guy Paulin M., Happi, Gervais M., Ngandjui, Yvan Anderson T., Tchouankeu, Jean Claude, Sewald, Norbert, Ali, Muhammad S., Kouam, Simeon F.
Format: Article
Language:English
Subjects:
antibacterial activity
Ekebergia senegalensis
Meliaceae
phenylpropanoid
Senegalin
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Summary:Senegalin (1), a new phenylpropanoid has been isolated from the stem bark of Ekebergia senegalensis A. Juss. along with twelve known secondary metabolites including coumarins 2-5, 4-hydroxy-3,5-methylbenzoic acid (6), pentacyclic triterpenoids 7-9, acyclic triterpenoids 10 and 11 and steroids 12 and 13, respectively. Their structures were elucidated with the help of spectroscopic techniques including 1 D- and 2 D-NMR. The antibacterial activity of the major compounds (2, 9-11) was evaluated on five bacterial strains. However, only compounds 2 and 11 showed a weak inhibition against Bacillus subtilis and Pseudomonas agarici. Furthermore, the chemotaxonomic significance of these compounds has also been elaborated.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1729151