Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis

• Published in: Natural product research 2021-12, Vol.35 (23), p.5066-5074
• Main Authors: Qiu, Lin, Xiao, Chao-Jiang, Shen, Yi, Xu, Wei, Liu, Xiao-Bo, Dong, Xiang, Jiang, Bei
• Format: Article
• Language: English
• Subjects: Acetic acid; analgesic; Analgesics; antioxidant; Aspirin; Astragalus bhotanensis; Biocompatibility; Cytotoxicity; Glucose; hydroxypropionylated glucose derivatives; Leguminosae; Liquiritigenin; Oleic acid; Physicochemical properties; Quebrachitol; Toxicity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2020.1777410

Four previously undescribed hydroxypropionylated d-glucose derivatives, astrabhotins A-D (1-4), along with ten known compounds α-d-glucose (5), β-d-glucose (6), quebrachitol (7), 3-hydroxypropionic acid (8), oleic acid (9), isoliquiritigenin (10), liquiritigenin (11), odoratin (12), 7β-hydroxysitosterol (13) and daucosterol (14), were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. Astrabhotin A (1) reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of 1 was stronger than the standard drug aspirin. In addition, compounds 1 and 3 showed significant antioxidant activities with IC 50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC 50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, respectively.