Traphanoside GO1, a new triterpenoid saponin from the aerial parts of Glinus oppositifolius with the inhibitory effect on PGE2 production in LPS-induced HepG2 cells

A new saponin, 3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid (Traphanoside GO1, 11) along with eleven compounds (1-10 and 12) were isolated from the aerial parts of Glinus oppositifolius. The structures of all isolates were elucidated by analyzing extensive 1 D-...

Full description

Saved in:
Bibliographic Details
Published in:Natural product research 2021-12, Vol.35 (23), p.5125-5131
Main Authors: Ha, Do Thi, Thu, Nguyen Thi, Ha, Tran Thanh, Thuy, Vu Huong, Van, Nguyen Huy, Luc, Tran Quang, Hue, Nguyen Thi Vinh
Format: Article
Language:English
Subjects:
3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid
Ethanol
Glinus oppositifolius
HepG2 cell
Lipopolysaccharides
NMR
Nuclear magnetic resonance
PGE2
Prostaglandin E2
Saponins
Traphanoside GO1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new saponin, 3-O-[α-ʟ-rhamnosyl-(1→3)-β-D-glucopyranosyl]-28-O-β-D-glucopyranosyl serjanic acid (Traphanoside GO1, 11) along with eleven compounds (1-10 and 12) were isolated from the aerial parts of Glinus oppositifolius. The structures of all isolates were elucidated by analyzing extensive 1 D- and 2 D-NMR and HR-ESI-MS, comparing with reported literature data. Compounds 7-8, 10-11, and 90% ethanol extract (GOE90) were evaluated for the inhibitory effect on PGE2 production from activated HepG2 cells. Among these, new compound 11 showed the most potent inhibitory activity by suppressing LPS-induced PGE2 production on the HepG2 cells.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1782405