A new cyclopeptide alkaloid from Clematis Florida

One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopo...

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Bibliographic Details
Published in:Natural product research 2022-04, Vol.36 (7), p.1693-1699
Main Authors: Wu, Ying, Zhang, Yi-Fan, Zhang, Hai-Tao, Ma, Xin-Hua, Yang, Na-Na, Feng, Shi-Biao, Zhong, Tian-Hua, Zhang, Yong-Hong
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
anti-inflammatory
Clematis - chemistry
Clematis florida
cyclopeptide alkaloid
Molecular Structure
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
Plant Roots - chemistry
RAW264.7 macrophages
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Summary:One new 14-membered ring cyclopeptide alkaloid, plenane A (1), along with six known compounds (2-7), was isolated from the roots of Clematis florida. Their structures were elucidated by means of NMR spectroscopic analysis and mass spectrometry. In addition, their anti- inflammatory effects on lipopolysaccharide-induced RAW264.7 macrophages were evaluated in vitro. The compounds 1, 2 and 6 exhibited potent indirect inhibitory effects, with IC 50 values of 40.92, 22.88 and 6.32 μM, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1809399