Polyhydroxylated steroid derivatives from the starfish Pentaceraster regulus

A new polyhydroxysteroid glycoside, regulusoside D (1), and a new polyhydroxylated steroid, (24S)-cholestane-3β,5,6β,8,15α,24-hexol (2), together with seven known compounds were purified from the starfish Pentaceraster regulus collected near Con Co Islands, Vietnam. The structure elucidation was con...

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Bibliographic Details
Published in:Natural product research 2022-05, Vol.36 (9), p.2223-2229
Main Authors: Vien, Le Thi, Hanh, Tran Thi Hong, Quang, Tran Hong, Cuong, Nguyen Xuan, Thao, Do Thi, Nam, Nguyen Hoai, Thung, Do Cong, Kiem, Phan Van, Minh, Chau Van
Format: Article
Language:English
Subjects:
Animals
Glycosides - chemistry
Glycosides - pharmacology
Magnetic Resonance Spectroscopy
Mice
NO production
Oreasteridae
Pentaceraster regulus
polyhydroxylated steroid
RAW 264.7 Cells
Starfish - chemistry
Steroids - chemistry
Steroids - pharmacology
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Summary:A new polyhydroxysteroid glycoside, regulusoside D (1), and a new polyhydroxylated steroid, (24S)-cholestane-3β,5,6β,8,15α,24-hexol (2), together with seven known compounds were purified from the starfish Pentaceraster regulus collected near Con Co Islands, Vietnam. The structure elucidation was confirmed by extensive analysis of their NMR and HR-QTOF mass experiments. Among isolated compounds, regulusoside D (1), (24S)-cholestane-3β,5,6β,8,15α,24-hexol (2), granulatoside A (4), 5α-cholestane-3β,6β,7α,15α,16β,26-hexol (6), 5α-cholestane-3β,6β,7α,8β,15α,16β,26-heptol (7) and 5α-cholestane-3β,6α,8,15α,16β,26-hexol (8) exhibited strong inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC 50 values of 9.13 ± 1.17, 9.19 ± 0.77, 8.63 ± 3.31, 12.61 ± 0.51, 14.83 ± 3.02 and 10.98 ± 1.22 µM, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1826478