A new depsidone from the lichen Usnea ceratina Arch

Chemical investigation of the lichen Usnea ceratina Arch led to the isolation of five depsidones, including one new compound ceratinalone (1) along with four known compounds bailesidone (2), stictic acid (3), 8′-O-methylstictic acid (4) and 8′-O-ethylstictic acid (5). The structures were determined...

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Bibliographic Details
Published in:Natural product research 2022-05, Vol.36 (9), p.2263-2269
Main Authors: Bui, Van-Muoi, Duong, Thuc-Huy, Chavasiri, Warinthorn, Nguyen, Kim-Phi-Phung, Huynh, Bui-Linh-Chi
Format: Article
Language:English
Subjects:
Animals
Ascomycota
ceratinalone
cytotoxic activity
Depsides - chemistry
Depsides - pharmacology
depsidone
Humans
Lactones
Lichen Usnea ceratina Arch
Lichens
Parmeliaceae
Usnea - chemistry
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Summary:Chemical investigation of the lichen Usnea ceratina Arch led to the isolation of five depsidones, including one new compound ceratinalone (1) along with four known compounds bailesidone (2), stictic acid (3), 8′-O-methylstictic acid (4) and 8′-O-ethylstictic acid (5). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. Compounds 1 and 4 were evaluated the cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer), HepG2 (liver hepatocellular carcinoma), and MCF-7 (human breast cancer) cell lines, showing the moderate activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1828405