New 3,4-seco-diterpene and coumarin derivative from the leaves of Trigonostemon flavidus Gagnep

Two new compounds named trigoflavidus A (1) and trigoflavidus B (2), and eight known compounds, trigoflavidone (3), heterophypene (4), howpene C (5), 3,4-seco-sonderianol (6), trigonochinene C (7), fraxidin (8), isofraxidin (9), and isofraxetin (10) were isolated from the leaves of Trigonostemon fla...

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Bibliographic Details
Published in:Natural product research 2022-07, Vol.36 (13), p.3247-3254
Main Authors: Ban, Ninh Khac, Linh, Tran My, Mai, Nguyen Chi, Tai, Bui Huu, Nhiem, Nguyen Xuan, Hoang, Nguyen Huy, Kiem, Phan Van
Format: Article
Language:English
Subjects:
Cell lines
Cell viability
Chromatography
Coumarin
Cytotoxicity
Diterpenes
NMR
Nuclear magnetic resonance
secoditerpene
trigoflavidus A
trigoflavidus B
Trigonostemon
Trigonostemon flavidus
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Summary:Two new compounds named trigoflavidus A (1) and trigoflavidus B (2), and eight known compounds, trigoflavidone (3), heterophypene (4), howpene C (5), 3,4-seco-sonderianol (6), trigonochinene C (7), fraxidin (8), isofraxidin (9), and isofraxetin (10) were isolated from the leaves of Trigonostemon flavidus Gagnep. by various chromatographic methods. Their chemical structures were elucidated via UV, IR, HR-ESI-MS and NMR spectroscopic methods and divided into two groups including six 3,4-seco-diterpenes (1, 3-7) and four coumarins (2, 8-10). Absolute configurations at stereocenters of compound 1 were confirmed by comparison of its CD spectra with those of the TD-DFT calculations. At a concentration of 30 µM, compounds 1-10 exhibited weak cytotoxic activity toward LU1, HepG2, MCF7, and SKMel2 human cell lines (cell viability all over 50%).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1851225