A new dibenzofuran derivative from the stem bark of Scyphocephalium ochocoa with anti-inflammatory and cytotoxic activities

The phytochemical investigation of the dichloromethane/methanol (1:1) extract of the stem bark of Scyphocephalium ochocoa, led to the isolation of one new dibenzofuran derivative, named scyphocephalione A (1), along with three other compounds, including epicatechin (2), gentisic acid (3) and myo-ino...

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Bibliographic Details
Published in:Natural product research 2022-03, Vol.36 (6), p.1503-1514
Main Authors: Feuya Tchouya, Guy Raymond, Foundikou, Hibrahim, Mbiantcha, Marius, Kezetas, Jean Jules Bankeu, Bongui, Jean-Bernard, Tchouankeu, Jean Claude, Lebibi, Jacques, Dethe, Dattatraya H.
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Anti-inflammatory agents
Anti-Inflammatory Agents - analysis
Chemical activity
Chemical compounds
Chemical modification
Chemiluminescence
cytotoxic activity
Cytotoxicity
Dibenzofuran
Dibenzofurans
Dichloromethane
Dihydroxybenzoic acid
Enzyme-linked immunosorbent assay
Epicatechin
Gentisic acid
Inflammatory diseases
Inositol
Inositols
NMR
Nuclear magnetic resonance
Phytochemicals - analysis
Plant Bark - chemistry
Plant Extracts - chemistry
scyphocephalione A
Scyphocephalium ochocoa
Stems
Toxicity
Tumor necrosis factor-α
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Summary:The phytochemical investigation of the dichloromethane/methanol (1:1) extract of the stem bark of Scyphocephalium ochocoa, led to the isolation of one new dibenzofuran derivative, named scyphocephalione A (1), along with three other compounds, including epicatechin (2), gentisic acid (3) and myo-inositol (4). The structures of all the compounds were established with help of spectroscopic data including IR, UV, MS, 1 D- and 2 D-NMR, as well as by comparison with previously reported data in literature, and chemical modification. All the compounds were obtained from the genus Scyphocephalium for the first time. The anti-inflammatory activity (using chemiluminescence technique) of the crude extract and compound 1, together with NO inhibition (using ELISA), TNF-α (using ELISA) and MCF-7 cells cytotoxicity effects (using MTT assay) of compound 1 were assessed. From the results obtained, compound 1 could be considered as a promising chemotherapeutic agent for the treatment of inflammatory diseases.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1894561