Three new cytotoxic stilbene dimers from paphiopedilum dianthum

Three new stilbene dimers, paphiodianthins A-C (1-3), and nine known stilbenes, lignan and flavonoids (4-12) were isolated from the roots and leaves of Paphiopedilum dianthum (Orchidaceae). The structures of new compounds were elucidated from their NMR, HRESIMS and IR spectroscopic data. Cytotoxic a...

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Bibliographic Details
Published in:Natural product research 2023-11, Vol.37 (21), p.3685-3693
Main Authors: Lertnitikul, Nonthalert, Liangsakul, Jatupol, Jianmongkol, Suree, Suttisri, Rutt
Format: Article
Language:English
Subjects:
Cancer
Chemotherapy
Cytotoxicity
Dimers
Doxorubicin
Flavonoids
Lignans
Mitoxantrone
NMR
Nuclear magnetic resonance
Orchidaceae
Paphiopedilum dianthum
Stilbene
stilbenes
Tumor cell lines
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Summary:Three new stilbene dimers, paphiodianthins A-C (1-3), and nine known stilbenes, lignan and flavonoids (4-12) were isolated from the roots and leaves of Paphiopedilum dianthum (Orchidaceae). The structures of new compounds were elucidated from their NMR, HRESIMS and IR spectroscopic data. Cytotoxic activity of all isolated compounds was evaluated by in vitro MTT assay against two human cancer cell lines (MCF-7, Caco-2), doxorubicin-resistant and mitoxantrone-resistant MCF-7 sublines, as well as a normal cell line (NIH/3T3). Stilbenes 1, 3, 10 and 11 were strongly cytotoxic to both cancer cell lines with IC 50 values ranging from 0.50 to 4.51 µM. Compounds 1, 10 and 11 were also active against chemotherapy-resistant MCF-7 sublines.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2101049