Two new terpenoid glycosides from Isodon macrocalyx

One previously undescribed tricyclo-diterpenoid saponin (1), one undescribed dammarane triterpenoid saponin (2) and four known triterpenoids (3-6) were isolated from the aerial part of Isodon macrocalyx. Their structures were determined using 1 D- and 2 D-NMR, HRESIMS, and comparison of their spectr...

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Bibliographic Details
Published in:Natural product research 2024, Vol.38 (2), p.220-226
Main Authors: Liang, Xiaoqin, Chang, Yanling, Guan, Xinlan, Huang, Yan, Pan, Liwei, Li, Jun, Li, Jian
Format: Article
Language:English
Subjects:
anti-HBV
Diterpenes
Glycosides
Glycosides - chemistry
Glycosides - pharmacology
Isodon - chemistry
Isodon macrocalyx
Lamiaceae
macrocalyxoside A
macrocalyxoside B
Molecular Structure
NMR
Nuclear magnetic resonance
Plant Extracts - chemistry
Saponins
Terpenes - pharmacology
Triterpenoids
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Summary:One previously undescribed tricyclo-diterpenoid saponin (1), one undescribed dammarane triterpenoid saponin (2) and four known triterpenoids (3-6) were isolated from the aerial part of Isodon macrocalyx. Their structures were determined using 1 D- and 2 D-NMR, HRESIMS, and comparison of their spectroscopic data with previously reported data. The isolates were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compounds 2 and 3 exhibited moderate anti-HBV activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2113997