Chemical constituents of Impatiens parvisepala and their α-glucosidase inhibition activity

The first chemical study of the whole Impatiens parvisepala S. X. Yu & Y. T. Hou led to the isolation of a new triterpene saponin, named Iparvisepala-1 (6) along with ten known compounds, which cover three flavonoid glycosides (1-3), one dihydrochalcone glucoside (4), one triterpenoid saponin (5...

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Bibliographic Details
Published in:Natural product research 2023-08, Vol.37 (16), p.2647-2652
Main Authors: Thuy Linh, Nguyen Thi, Thuy, Trinh Thi, Tam, Nguyen Thanh, Cham, Ba Thi, Tai, Bui Huu, Thao, Do Thi, Thien, Dinh Gia, Chinh, Vu Tien, Hoang Anh, Nguyen Thi
Format: Article
Language:English
Subjects:
Balsaminaceae
Chemical activity
Flavone glycosides
flavonoid glycoside
Flavonoids
Glucosidase
Glucosides
Glycosides
Impatiens parvisepala
NMR
Nuclear magnetic resonance
Saponins
triterpenoid saponin
α-Glucosidase
α-glucosidase inhibition
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Summary:The first chemical study of the whole Impatiens parvisepala S. X. Yu & Y. T. Hou led to the isolation of a new triterpene saponin, named Iparvisepala-1 (6) along with ten known compounds, which cover three flavonoid glycosides (1-3), one dihydrochalcone glucoside (4), one triterpenoid saponin (5), one triterpene (7) and four miscellaneous compounds (8-11). Their structures were elucidated by MS, NMR spectroscopic analyses as well as by comparisons of spectra data with those of the related published literatures. Additionally, flavonoid glucoside 2 showed impressive effect on α-glucosidase inhibition with the IC 50 value of 12.53 ± 0.39 µM, much better than that of the positive control acabose (IC 50 = 197.53 ± 2.68 µM).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2127705