Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B

Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated on the basis of comprehensive spectroscopi...

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Bibliographic Details
Published in:Natural product research 2024-05, Vol.38 (9), p.1503-1509
Main Authors: Xu, Zhao-Long, Li, Ben-Chao, Huang, Li-Li, Lv, Liu-Xia, Luo, Yan, Xu, Wei-Feng, Yang, Rui-Yun
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
antibacterial activities
Antibacterial activity
Antibiotics
Bacillus subtilis
cytochalasins
Cytochalasins - chemistry
E coli
Endophytes
endophytic fungus
Escherichia coli
Fungi
Herbal medicine
Medicinal plants
Molecular Structure
Spectroscopic analysis
Xylaria
Xylaria sp
Xylariales - chemistry
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Summary:Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. Compound 2 displayed moderate antibacterial activities against Bacillus subtilis and Escherichia coli with MIC values of 25 and 12.5 μg/mL, respectively.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2153362