Identification and nitric oxide production inhibitory activity of phenolic derivatives from the trunks of Gnetum latifolium

Phytochemical investigation of the trunks from led to the isolation of a novel phenolic glucoside, 2 -2,4-di-(3,4-dihydroxyphenyl)but-2-en-1-yl- - -D-glucopyranoside ( ), along with five known stilbene derivatives ( ). Their structures were determined mainly using high-resolution electrospray ionisa...

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Published in:Natural product research 2024-02, p.1-5
Main Authors: Hoa, Nguyen Thi Thu, Cham, Ba Thi, Hoang Anh, Nguyen Thi, Tuan Hiep, Nguyen, Anh, Nguyen Thi Kim, Nhung, Le Thi Hong, Adorisio, Sabrina, Delfino, Domenico V, Thuy, Trinh Thi, Thuy Linh, Nguyen Thi
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Language:English
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Summary:Phytochemical investigation of the trunks from led to the isolation of a novel phenolic glucoside, 2 -2,4-di-(3,4-dihydroxyphenyl)but-2-en-1-yl- - -D-glucopyranoside ( ), along with five known stilbene derivatives ( ). Their structures were determined mainly using high-resolution electrospray ionisation mass spectrometry and nuclear magnetic resonance spectroscopic analyses, followed by comparisons of observed spectral data with reported values. The novel compound in was found to be useful as a chemotaxonomic marker. Biological evaluation revealed that compound had remarkable inhibitory effects on nitric oxide production, with a half-maximal inhibitory concentration (IC ) value of 4.85 ± 0.20 µM, which was much higher than that of the positive control dexamethasone (IC = 14.20 ± 0.54  M).
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2024.2320729