A new bicyclo [3.3.1]nonadienemethanol-type lignan from the leaves of Taxus wallichiana Zucc

Following an α-glucosidase inhibitory activity-guided phytochemical study, a rare new bicyclo[3.3.1]nonadienemethanol-type lignan named 9,9'-oxidolanceolatanin B ( ) and four known lignans, lanceolatanin B ( ), pinoresinol ( ), syringaresinol ( ), and medioresinol ( ), were isolated from a CHCl...

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Bibliographic Details
Published in:Natural product research 2024-10, p.1-8
Main Authors: Dang, Phu Hoang, Tran, Tu Hoai, Le, Tho Huu, Nguyen, Mai Thanh Thi, Nguyen, Nhan Trung
Format: Article
Language:English
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Summary:Following an α-glucosidase inhibitory activity-guided phytochemical study, a rare new bicyclo[3.3.1]nonadienemethanol-type lignan named 9,9'-oxidolanceolatanin B ( ) and four known lignans, lanceolatanin B ( ), pinoresinol ( ), syringaresinol ( ), and medioresinol ( ), were isolated from a CHCl -soluble fraction of Zucc. leaves. The absolute configuration of 9,9'-oxidolanceolatanin B was elucidated based on NMR spectroscopic interpretation and ECD data. All isolated compounds - showed stronger α-glucosidase inhibitory potency than the positive control, acarbose. This data could support the conceit that leaves could be a promising source for plant-based anti-diabetic drug discovery.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2024.2414407