cAMP Phosphodiesterase Activity Evaluation in Human Carcinoma of Salivary Glands

The aim of this study was to evaluate differences of cAMP-PDE activity in human salivary glands, between a control group and some different benign tumours groups and, where present, with 2 malignant tumors groups. The value of the enzymatic activity in the groups analysed was 50% lower than control...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2006-06, Vol.25 (9-11), p.1113-1117
Main Authors: Spoto, G., della Malva, M., Rubini, C., Fioroni, M., Piattelli, A., Serra, E., Di Nicola, M., Santoleri, F.
Format: Article
Language:English
Subjects:
3',5'-Cyclic-AMP Phosphodiesterases - metabolism
cAMP
Carcinoma
Carcinoma - enzymology
Case-Control Studies
Cyclic AMP - chemistry
Cyclic nucleotides
Disease Progression
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Neoplasm Metastasis
Nucleotides, Cyclic - chemistry
Phosphodiesterase
Salivary Gland Neoplasms - enzymology
Salivary glands
Salivary Glands - enzymology
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Summary:The aim of this study was to evaluate differences of cAMP-PDE activity in human salivary glands, between a control group and some different benign tumours groups and, where present, with 2 malignant tumors groups. The value of the enzymatic activity in the groups analysed was 50% lower than control samples. The differences between the control group (82 ± 7.9 nmols/mg of protein) and the 3 pathologic groups (Benign A: 44 ± 6.2; Malignant A: 40  ± 16; Benign B: 40  ± 14.2; Malign A: 9.1; Benign C: 22 nmols/mg of protein) are statistically significant.
ISSN:1525-7770
1532-2335
DOI:10.1080/15257770600894162