Comparative serologic profiles of hepatitis B Virus (HBV) between HIV/HBV co-infected and Hbv mono-infected patients in Ile-Ife, Nigeria

Hepatitis B virus (HBV) infects about 2 billion people globally and accounts for mortality of about 800,000 from liver cirrhosis and hepatocellular carcinoma. Sub-Saharan Africa accounts for 70% of the Human Immunodeficiency Virus (HIV) global burden. HIV/HBV co-infection results in the early develo...

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Bibliographic Details
Published in:Journal of immunoassay & immunochemistry 2021-11, Vol.42 (6), p.633-647
Main Authors: Osasona, Oluwadamilola Gideon, Adewale-Fashoro, Opeoluwa, Olumade, Testimony J., Oguzie, Judith, George, Uwem, Ariyo, Olumuyiwa Elijah, Oguntoye, Oluwatosin Oluwagbenga
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Biomarkers
Cirrhosis
Co-infection
Coinfection
Comparative
Complications
Enzyme-linked immunosorbent assay
Female
HBV
Hepatitis
Hepatitis B
Hepatitis B - complications
Hepatitis B Antibodies
Hepatitis B e antigen
Hepatitis B e Antigens
Hepatitis B surface antigen
Hepatitis B Surface Antigens
Hepatitis B virus - immunology
Hepatocellular carcinoma
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Liver cirrhosis
Liver Neoplasms
Male
Middle Aged
Nigeria
Public health
serologic
Serology
Viruses
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Summary:Hepatitis B virus (HBV) infects about 2 billion people globally and accounts for mortality of about 800,000 from liver cirrhosis and hepatocellular carcinoma. Sub-Saharan Africa accounts for 70% of the Human Immunodeficiency Virus (HIV) global burden. HIV/HBV co-infection results in the early development of HBV complications, alterations of serological biomarkers of HBV. Two hundred and fifty patients with HIV/AIDS were screened for HBV and 20 (8%) were identified. The same number of HBV mono-infected individuals were recruited into the study and subsequently, HBV serological profiles which include HBsAg, HBsAb, HBeAg, HBeAb, HBcAbIgM, and HBcAbIgG were assayed using HBV ELISA kits. Mean age of patients in the HBV/HIV cohort was 45.5 years while the HBV mono-infected infected cohort was 30.5 years. The majority of the HBV/HIV co-infected individuals were females (85%). The frequency of HBeAg among HIV/HBV co-infected cohort was 25% and 15% for HBV mono-infected, while the frequency of HBeAb was higher (60%) among the cohort of HBV/HIV co-infected patients in comparison with the HBV mono-infected cohorts (50%). Two patients among the HIV/HBV co-infected cohort have the isolated anti-HBcAg serologic pattern. The study broadened the available evidence of comparative serologic profiles of Hepatitis B virus between cohorts of HBV/HIV co-infected individuals and HBV mono-infected patients in Nigeria.
ISSN:1532-1819
1532-4230
DOI:10.1080/15321819.2021.1924197