Light chain 3 immunoexpression in psoriasis

Autophagy dysregulation is involved in many diseases. The implication of autophagy in psoriasis pathogenesis is still uncertain. To investigate the role of Light Chain 3 (LC3), a good marker for autophagy, in psoriatic skin based on immunohistochemical study and correlate its expression - for the fi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of immunoassay & immunochemistry 2022-07, Vol.43 (4), p.365-383
Main Authors: Samaka, Rehab M., Marae, Alaa, Faried, Manar, Bazid, Heba A.S.
Format: Article
Language:English
Subjects:
Autophagy
Biopsy
Chains
Immunohistochemistry
LC3
Pathogenesis
Psoriasis
skin
Skin diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autophagy dysregulation is involved in many diseases. The implication of autophagy in psoriasis pathogenesis is still uncertain. To investigate the role of Light Chain 3 (LC3), a good marker for autophagy, in psoriatic skin based on immunohistochemical study and correlate its expression - for the first time to the best of our knowledge - to clinicopathological data Prospective case-control study was conducted on 60 subjects (30 control, 30 psoriasis patients). Skin biopsies from control, lesional, and perilesional skin were processed for routine histopathological examination and LC3 immunoreaction assessment. There was a significant upregulation of the epidermal and dermal LC3 immunoreaction in the lesional skin compared with the control and perilesional skin specimens (P
ISSN:1532-1819
1532-4230
DOI:10.1080/15321819.2021.2018708