Prevalence and spatiotemporal distribution of rotavirus diarrhea among children younger than five years old in Lagos, Nigeria

Data on spatiotemporal distribution of rotavirus diarrhea are limited in many endemic settings. This study determined the prevalence and seasonal distribution of rotavirus among Nigerian children with diarrhea. Here, a total of 406 fecal samples were collected from patients attending six health faci...

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Bibliographic Details
Published in:Journal of immunoassay & immunochemistry 2023-03, Vol.44 (2), p.117-132
Main Authors: Eugenia Afocha, Ebelechukwu, Abiodun Iwalokun, Bamidele, Deji-Agboola, Mopelola Anotu, Ayorinde James, Babatunde, Abayomi Banjo, Taiwo, Adu, Festus, Chukwujekwu Ezechi, Oliver, Adegbola, Richard, Lawal Salako, Babatunde
Format: Article
Language:English
Subjects:
Antigens
Antigens, Viral - genetics
Child
Child, Preschool
Children
Diarrhea
Diarrhea - epidemiology
Enzyme-linked immunosorbent assay
Feces
Female
Genotype
Health care facilities
Humans
Immunoassay
Infant
Male
Nigeria
Nigeria - epidemiology
Prevalence
Reverse transcription
Rotavirus
Rotavirus - genetics
Rotavirus diarrhea
Rotavirus Infections - epidemiology
Seasonal distribution
Spatial distribution
spatiotemporal distribution
Temporal distribution
Viruses
VP7 gene
younger than five years old children
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Summary:Data on spatiotemporal distribution of rotavirus diarrhea are limited in many endemic settings. This study determined the prevalence and seasonal distribution of rotavirus among Nigerian children with diarrhea. Here, a total of 406 fecal samples were collected from patients attending six health facilities in Lagos between January - December 2019. Socio-demographic data of each enrolled child were collected. Rotavirus VP6 antigen was detected by enzyme-linked immunoassay (ELISA) and confirmation by VP7 gene detection by reverse transcription polymerase-chain reaction. The overall rotavirus diarrhea prevalence was 16.3% by ELISA with children above 2 years having 29.2% of this prevalence and higher occurrence in females (59.1%) than males (40.9%) (P 
ISSN:1532-1819
1532-4230
DOI:10.1080/15321819.2022.2159430