The role of extracellular DNA (exDNA) in cellular processes

Nowadays, extracellular DNA or circulating cell-free DNA is considered to be a molecule with clinical applications (diagnosis, prognosis, monitoring of treatment responses, or patient follow-up) in diverse pathologies, especially in cancer. Nevertheless, because of its molecular characteristics, it...

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Bibliographic Details
Published in:Cancer biology & therapy 2021-04, Vol.22 (4), p.267-278
Main Authors: Fernández-Domínguez, Ileana J., Manzo-Merino, Joaquin, Taja-Chayeb, Lucia, Dueñas-González, Alfonso, Pérez-Cárdenas, Enrique, Trejo-Becerril, Catalina
Format: Article
Language:English
Subjects:
DNA - genetics
Extracellular DNA
extracellular DNA traps
horizontal DNA transfer
Humans
Neoplasms - diagnosis
Neoplasms - genetics
oxidized DNA
Prognosis
Review
second messenger DNA
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Summary:Nowadays, extracellular DNA or circulating cell-free DNA is considered to be a molecule with clinical applications (diagnosis, prognosis, monitoring of treatment responses, or patient follow-up) in diverse pathologies, especially in cancer. Nevertheless, because of its molecular characteristics, it can have many other functions. This review focuses on the participation of extracellular DNA (exDNA) in fundamental processes such as cell signaling, coagulation, immunity, evolution through horizontal transfer of genetic information, and adaptive response to inflammatory processes. A deeper understanding of its role in each of these processes will allow development of better tools to monitor and control pathologies, as well as helping to generate new therapeutic options, beyond the applicability of DNA in liquid biopsy.
ISSN:1538-4047
1555-8576
DOI:10.1080/15384047.2021.1890319