The Effect of the 50 g Glucose Challenge Test on The Thiol/Disulfide Homeostasis in Pregnancy

Aim: A 50 g glucose challenge test (GCT) is recommended for screening all pregnant women for gestational diabetes mellitus. In this study, the effect of GCT on the thiol/disulfide balance was investigated. Methods: One-hundred women that underwent a 50 g GCT at 24-28 weeks of gestation (63 positive...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2018-05, Vol.37 (3), p.147-156
Main Authors: Mertoğlu, Cuma, Gunay, Murat, Siranli, Gulsah, Kulhan, Mehmet, Gok, Gamze, Erel, Özcan
Format: Article
Language:English
Subjects:
50 g glucose challenge test
Adult
Blood Glucose - analysis
Case-Control Studies
Diabetes, Gestational - blood
Diabetes, Gestational - diagnosis
Disulfides - blood
Female
Gestational diabetes mellitus
Glucose Tolerance Test - methods
Homeostasis - physiology
Humans
Oral glucose tolerance test
Oxidative stress
Oxidative Stress - physiology
Pregnancy
Prospective Studies
Sulfhydryl Compounds - blood
Thiol/disulfide homeostasis
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Summary:Aim: A 50 g glucose challenge test (GCT) is recommended for screening all pregnant women for gestational diabetes mellitus. In this study, the effect of GCT on the thiol/disulfide balance was investigated. Methods: One-hundred women that underwent a 50 g GCT at 24-28 weeks of gestation (63 positive and 37 negative results) were evaluated in terms of thiol/disulfide in serum samples at test hours 0 and 1. Results: Compared to the baseline values (hour 0), after the glucose load (hour 1), the thiol and native thiol/total thiol (p < 0.0001) of the GCT-positive women were reduced whereas the values of glucose, disulfide, disulfide/native thiol, disulfide/total thiol (p < 0.0001) and total thiol increased (p = 0.018). Conclusion: In GCT-positive pregnant individuals, the glucose load increases oxidative stress by changing the thiol/disulfide homeostasis. Such an effect is not observed in healthy pregnancies.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2018.1453002