Possible Role of TGF- β 1, MMP-2, E-CAD, β -Catenin and Antioxidants in Pathogenesis of Placenta Accreta

• Published in: Fetal and pediatric pathology 2021-06, Vol.40 (3), p.222-232
• Main Authors: El-Hussieny, Maram, Mohammed, Enas Mostafa, Zenhom, Nagwa Mohamed, Refaie, Marwa Monier, Okasha, Ahmed Mohamed, Tawab, Manal Abd El
• Format: Article
• Language: English
• Subjects: Antigens, CD; Antioxidants; beta Catenin; Cadherins; Female; Humans; Matrix Metalloproteinase 2; Placenta Accreta; Pregnancy; Transforming Growth Factor beta1 - genetics
• ISSN: 1551-3815; 1551-3823
• DOI: 10.1080/15513815.2020.1843574

Placenta accreta (PA) can be life-threatening due to postpartum hemorrhage and may lead to cesarean hysterectomy. We investigated the expression of Matrix metalloproteinase-2 (MMP-2), β-catenin, E-cadherin (E-CAD), transforming growth factor β1 (TGF-β1), glutathione peroxidase 1 (GPx-1), reduced glutathione (GSH) and superoxide dismutase (SOD) in PA compared to controls to determine if alterations may contribute to PA. Materials and methods: Twenty six PA and 31 controls were evaluated immunohistochemically for expression of MMP-2, β-catenin and E-CAD on villous and extravillous trophoblasts. TGF-β1 and GPx-1 mRNA levels were evaluated by rt-PCR. We measured biochemical levels of GSH and SOD. Results: Significant increases of MMP-2 immunoexpression, GPx-1 mRNA, SOD and GSH levels, decreases in immunoexpression of E-CAD and β-catenin and TGF-β1 mRNA were found in PA. Conclusion: These findings suggest that loss of cell-cell adhesion and increased antioxidants level may have a role in PA.