A Multicenter Study of Clinicopathology and Immunohistochemical Distinction between Adult and Pediatric Large B-Cell Lymphoma

Introduction: Pediatric DLBCL is considered a homogenous group and has superior outcomes compared to adults. This study investigated the clinical pathology and immunohistochemical distinction between adult and pediatric large B-cell lymphoma. Methods: A cross-sectional study of 314 NHLs with the mor...

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Published in:Fetal and pediatric pathology 2023-05, Vol.42 (3), p.355-366
Main Authors: Phan, Thu Dang Anh, Duong, Tu Thanh, Thi Nhu Pham, Diem, Hoang Dang, Minh, Thanh Ly, Thien, Thi Tuyet Ngo, Hanh, Ngo, Dat Quoc, Trinh, Nguyen Dinh The, Le Ly, Uyen, Anh Thai, Tu, Thi Ngoc Hua, Ha, Thi Phuong Doan, Thao
Format: Article
Language:English
Subjects:
Adult
Child
Cross-Sectional Studies
diffuse large B-cell lymphoma (DLBCL)
DLBCL
GCB
Humans
large B-cell lymphoma (LBCL)
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - metabolism
Lymphoma, Large B-Cell, Diffuse - pathology
non-GCB
pleomorphic mantle cell lymphoma (MCL)
Prognosis
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Summary:Introduction: Pediatric DLBCL is considered a homogenous group and has superior outcomes compared to adults. This study investigated the clinical pathology and immunohistochemical distinction between adult and pediatric large B-cell lymphoma. Methods: A cross-sectional study of 314 NHLs with the morphology of diffuse pattern, large B-cell, and CD20 expression was investigated. Results: Of 314 cases, there were 6 cases of pleomorphic MCL (all in adults), 19 cases of Burkitt lymphoma (all in children), and 289 cases of DLBCL. Pediatric DLBCL had many striking differences: More frequency in extra-nodal sites; a higher proportion of centroblastic morphology; a predominance of GCB-type; a high proliferation rate; an infrequency of Bcl2 protein expression, and a lack of double-expresser lymphoma. Conclusions: Our study demonstrated the significant biological differences between adult and pediatric DLBCL.
ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2022.2120786