Synthesis, Characterization, and Cytotoxicity of Palladium(II) Complexes With Diimine/Diamine and N-Carbonyl-L-Phenylalanine Dianion

Six palladium(II) complexes, [Pd(bipy)(Bzphe-N,O)] (I-a), [Pd(bipy)(p-Mbzphe-N,O)]·2H 2 O (I-b), [Pd(bipy)(p-Nbzphe-N,O)]·2H 2 O (I-c), [Pd(phen)(Bmined by X-ray diffraction. The cytotoxicity test indicates that the complexes exert cytotoxic effects against KB, BGC-823, Bel-7402, and HL-60, but none...

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Bibliographic Details
Published in:Inorganic and nano-metal chemistry 2015-07, Vol.45 (7), p.1049-1056
Main Authors: Wang, Li-Wei, Liu, Si-Yuan, Wang, Jin-Jie, Peng, Wen, Li, Sheng-Hui, Zhou, Guo-Qiang, Qin, Xin-Ying, Wang, Shu-Xiang, Zhang, Jin-Chao
Format: Article
Language:English
Subjects:
Anions
Carbonyls
cytotoxicity
Diamines
diimine
N-carbonyl-L-phenylalanine dianion
Palladium
Palladium (II) complex
Phenylalanine
Reagents
Toxicity testing
X-ray diffraction
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Summary:Six palladium(II) complexes, [Pd(bipy)(Bzphe-N,O)] (I-a), [Pd(bipy)(p-Mbzphe-N,O)]·2H 2 O (I-b), [Pd(bipy)(p-Nbzphe-N,O)]·2H 2 O (I-c), [Pd(phen)(Bmined by X-ray diffraction. The cytotoxicity test indicates that the complexes exert cytotoxic effects against KB, BGC-823, Bel-7402, and HL-60, but none of them shows higher cytotoxicity than cisplatin. The structure-activity relationship suggests that bomined by X-ray diffraction. The cytotoxicity test indicates that the complexes exert cytotoxic effects against KB, BGC-823, Bel-7402, and HL-60, but none of them shows higher cytotoxicity than cisplatin. The structure-activity relationship suggests that both N-containing ligands and N-carbonyl reagent have important effect on cytotoxicity, however, the IC 50 values do not show definite correlation with their variation.
ISSN:1553-3174
2470-1556
1553-3182
2470-1564
DOI:10.1080/15533174.2013.862652