A Comparative Antimicrobial Study In Between a Quinoline Drug and Its Complexes: Spectral, Kinetic, and Molecular Modeling Investigations

• Published in: Inorganic and nano-metal chemistry 2015-11, Vol.45 (11), p.1743-1757
• Main Authors: Al-hazmi, Gamil A. A., Saad, Fawaz A.
• Format: Article
• Language: English
• Subjects: Antibiotics; Antiinfectives and antibacterials; Copper; Diffraction patterns; drug complexes; Investigations; Ligands; modeling and biological activity; Modelling; Molecular structure; NMR; Nuclear magnetic resonance; Palladium; Platinum; Quinoline; spectral; Thermogravimetric analysis; Zinc
• ISSN: 1553-3174; 2470-1556; 1553-3182; 2470-1564
• DOI: 10.1080/15533174.2015.1016233

A series of ciproH antibiotic drug complexes was prepared. The chosen metal ions have a great history in the medicinal field, which may introduce a sensitive antibiotic appearance in comparing with the free ciproH drug. All the prepared complexes are discussed based on spectral (IR, 1 H NMR, 13 C NMR, UV-vis, ESR, X-ray, and SEM), thermal, and analytical data. The ligand coordinates through its zwitterionic form as bidentate mode through COO − and C=O groups. The octahedral stereo structure was proposed for Cu(II), Zn(II), and Pt(IV) complexes, square planar with Pd(II) and Pt(II) complexes, and square-pyramidal with VO(II). The amorphous nature was proposed for all investigated complexes based on the X-ray diffraction patterns although, the nanocrystalline appearance of starting ligand. Thermogravimetric analysis is also used to support the presence or absence of solvent molecules conjugated with the complexes isolated physically or chemically. Applying Chem-office program, a suitable modeling structure of each investigated complex was drawn. A comparative antibacterial study was concerned using Gram -ve and Gram +ve bacteria. The data reflect the inhibiting effect of some complexes more than the drug itself, which is considered an introductory step in introducing competitive drug.