Role of activation of lipid peroxidation in the mechanisms of acute methanol poisoning

Context: The role of activation of lipid peroxidation in the mechanisms of acute methanol poisoning has not been studied. Objective: We measured the concentrations of lipid peroxidation markers in acutely intoxicated patients with known serum concentrations of methanol and leukotrienes. Methods: Blo...

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Published in:Clinical toxicology (Philadelphia, Pa.) Pa.), 2018-10, Vol.56 (10), p.893-903
Main Authors: Hlusicka, Jiri, Loster, Tomas, Lischkova, Lucie, Vaneckova, Manuela, Seidl, Zdenek, Diblik, Pavel, Kuthan, Pavel, Urban, Pavel, Navratil, Tomas, Kacer, Petr, Zakharov, Sergey
Format: Article
Language:English
Subjects:
Activation, Metabolic - physiology
Alcoholism - physiopathology
Aldehydes - blood
Aldehydes - metabolism
Biomarkers - blood
Cysteine Proteinase Inhibitors - blood
Cysteine Proteinase Inhibitors - metabolism
Female
Follow-Up Studies
Humans
lipid oxidative damage
lipid peroxidation
Lipid Peroxidation - physiology
Male
Methanol - blood
Methanol - poisoning
Middle Aged
neuroinflammation
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Summary:Context: The role of activation of lipid peroxidation in the mechanisms of acute methanol poisoning has not been studied. Objective: We measured the concentrations of lipid peroxidation markers in acutely intoxicated patients with known serum concentrations of methanol and leukotrienes. Methods: Blood serum samples were collected from 28 patients hospitalized with acute intoxication and from 36 survivors 2 years after discharge. In these samples, concentrations of 4-hydroxy-trans-2-hexenal (HHE), 4-hydroxynonenal (HNE), and malondialdehyde (MDA) were measured using the method of liquid chromatography-electrospray ionization-tandem mass spectrometry. Results: The maximum acute serum concentrations of all three lipid oxidative damage markers were higher than the follow-up serum concentrations: HNE 71.7 ± 8.0 ng/mL versus 35.4 ± 2.3 ng/mL; p 
ISSN:1556-3650
1556-9519
DOI:10.1080/15563650.2018.1455980