Combination of infra-red light with nanogold targeting macrophages in the treatment of Leishmania major infected BALB/C mice

• Published in: Cutaneous and ocular toxicology 2022-01, Vol.41 (1), p.18-24
• Main Authors: Yasak Guner, Rukiye, Berksoy Hayta, Sibel, Tosun, Mustafa, Akyol, Melih, Ozpınar, Necati, Akın Polat, Zubeyde, Egilmez, Reyhan, Celikgün, Serkan, Cam, Selim
• Format: Article
• Language: English
• Subjects: BALB/c; cutaneous leishmaniasis; macrophage-specific antibody; nanogold; phototherapy
• ISSN: 1556-9527; 1556-9535
• DOI: 10.1080/15569527.2021.2000430

In the treatment of cutaneous leishmaniasis (CL), developing drug resistance, existing toxic effects of drugs and failure respond to treatment cause the need to try different treatment methods. We investigated the effect of gold-conjugated macrophage-specific antibody on amastigotes under infra-red light for the treatment of CL. Female BALB/c (4-8 weeks old, 20 ± 5 g weight) mice were used in the study. The L. major strain was inoculated on the soles of mice in amastigote form and subpassed. Nanogold (Au), Au + macrophage-specific antibody (MSA) modification and near infra-red (NIR) (5 seconds) were applied to mice groups that developed cutaneous leishmaniasis on their soles. On the 5th and 10th days of the treatment, the lesions were examined clinically and pathologically. When the erythema values were examined, the highest decrease was calculated in the Au + MSA + NIR group in the measurements made on the 10 th day (p