Evaluation of possible protective role of Chrysin against arsenic-induced nephrotoxicity in rats

Arsenic is a heavy metal having great scientific concern due to its toxic effects. Chrysin is a flavone found in honey and plants. This study was designed to evaluate the therapeutic effects of chrysin against arsenic incited nephrotoxicity in rats. Animals were separated into four different groups...

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Bibliographic Details
Published in:Toxin reviews 2022-10, Vol.41 (4), p.1237-1245
Main Authors: Ijaz, Muhammad Umar, Jabeen, Faryal, Ashraf, Asma, Imran, Muhammad, Ehsan, Nazia, Samad, Abdul, Saleemi, Muhammad Kashif, Iqbal, Javed
Format: Article
Language:English
Subjects:
antioxidant enzymes
Arsenic
Chrysin
DNA damage
nephrotoxicity
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Summary:Arsenic is a heavy metal having great scientific concern due to its toxic effects. Chrysin is a flavone found in honey and plants. This study was designed to evaluate the therapeutic effects of chrysin against arsenic incited nephrotoxicity in rats. Animals were separated into four different groups and designated as control, arsenic (10 mg/kg) treated, arsenic + chrysin (10 mg/kg and 50 mg/kg respectively) treated and chrysin (50 mg/kg) treated groups. After 30 days of trial, rats were dissected and antioxidant enzymes, renal damage markers, inflammatory markers, DNA damage and histopathology were observed. Catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione-S-transferase (GST) activities and glutathione (GSH) content were significantly (p 
ISSN:1556-9543
1556-9551
DOI:10.1080/15569543.2021.1993261